Modifying theNSsgene to improve live-attenuated vaccine for Rift Valley fever
نویسندگان
چکیده
منابع مشابه
Safety and immunogenecity of a live attenuated Rift Valley fever vaccine (CL13T) in camels
BACKGROUND Rift Valley fever is an emerging zoonotic viral disease, enzootic and endemic in Africa and the Arabian Peninsula, which poses a significant threat to both human and animal health. The disease is most severe in ruminants causing abortions in pregnant animals, especially sheep animals and high mortality in young populations. High mortality rates and severe clinical manifestation have ...
متن کاملTemperature-sensitive mutations for live-attenuated Rift Valley fever vaccines: implications from other RNA viruses
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to the African continent. RVF is characterized by high rate of abortions in ruminants and hemorrhagic fever, encephalitis, or blindness in humans. RVF is caused by the Rift Valley fever virus (RVFV: genus Phlebovirus, family Bunyaviridae). Vaccination is the only known effective strategy to prevent the disease, but there are n...
متن کاملRift Valley Fever Encephalitis
6. Innis B, Nisalak A, Nimmannitya S, Kusalerdchariya S, Chongswasdi V, Suntayakorn S, et al. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg 1989;40:418–27. 7. Guzman MG., Kouri G., and Halstead SB. Do escape mutants explain rapid increases in dengue case-fatality rates within epidemics? Lancet 2000;3...
متن کاملRift Valley Fever
Rift Valley fever (RVF) is a peracute or acute zoonotic disease of domestic ruminants. The virus is currently confined to the African continent and Arabian Peninsula. It is caused by a single serotype of a mosquito-borne virus of the Bunyaviridae family (genus Phlebovirus). The disease occurs in climatic conditions favouring the breeding of mosquito vectors and is characterised by abortion, neo...
متن کاملRift valley fever.
Rift Valley fever is a viral disease that affects domestic animals and humans. In humans, Rift Valley fever causes a flu-like disease but occasionally leads to high morbidity and mortality. The disease is generally known in the African continent. However, cases started to appear in Saudi Arabia and Yemen. The objective of this review is to give a general briefing about the epidemiology, ecology...
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ژورنال
عنوان ژورنال: Expert Review of Vaccines
سال: 2012
ISSN: 1476-0584,1744-8395
DOI: 10.1586/erv.12.106